There are several potential sources of unpublished information on trial methods and results (table). These sources can help to identify the existence and results of unpublished trials, as well as unreported outcomes within published trials. They can also provide methodological information that facilitates assessment of risk of bias, including the detection of discrepancies between unpublished and published methods.5 6 Systematic reviewers should consider using all potential information sources as part of their search strategy, while keeping in mind the strengths and limitations of each source (table). Users can search the main registry fields using key words related to the study topic, sponsor, recruitment status, and sites. When the same trial is registered in multiple registries, the WHO Search Portal displays similar records together to facilitate identification of duplicate records. Some registry websites also provide access to the history of changes to the registered information fields.
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